Abstract: Ｏｂｊｅｃｔｉｖｅ：To analyzes the efficacy and the timing of PD in neonatal acute kidney injury (AKI).
Ｍｅｔｈｏｄｏｌｏｇｙ：The neonates with acute renal injury treated with PD in Zhongda Hospital, Southeast University from June 2014 to December 2022 were collected.Retrospective collection of general baseline data, efficacy indicators before and after PD treatment, as well as postoperative complications after PD catheterization. Cox regression model was used to explore the influencing factors of prognosis in pediatric patients, and Wilcoxon signed rank test and Wilcoxon two sample comparison method were used to analyze the intra group and inter group efficacy comparison before and after PD treatment.
Ｒｅｓｕｌｔｓ：A total of 16 neonates were included. The Cox regression model results showed that AKI stage 3 ［P=0.037, HR=6.916, 95％CI (1.126, 42.492)］ is a risk factor affecting the prognosis of neonates.The study divided the neonates into operation incision group(OP,n=9)and improved percutaneous puncture group(Seldinger,n=7). The results showed that there was no significant difference in the efficacy between the two groups.The study divided the neonates into timely intervention with PD group(n=8)and delayed intervention with PD group(n=8), the urine volume significantly increased in the timely intervention group(P=0.036).Compared to the delayed intervention group, the timely intervention group had a more significant effect on correcting metabolic acidosis(P=0.009).All neonates were successfully implanted with PD catheters. There were 6 cases of postoperative complications, including 4 in the OP group and 2 in the Seldinger group.
Ｃｏｎｃｌｕｓｉｏｎ：PD is effective and safe in treating severe of neonatal AKI.We suggest that timely intervention of PD,which can improve the prognosis of neonates.The improved percutaneous puncture method has has fewer complications and better safety.

Key words: peritoneal dialysis, neonate, acute kidney injury, timing of intervention