ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2015, Vol. 24 ›› Issue (6): 562-566.

• 论文 • 上一篇    下一篇

抗疟药在狼疮性肾炎治疗中的应用

  

  • 出版日期:2015-12-28 发布日期:2015-12-29

Antimalarial agents in the treatment of lupus nephritis

  • Online:2015-12-28 Published:2015-12-29

摘要:

系统性红斑狼疮(SLE)是累及多系统的自身免疫性疾病,狼疮性肾炎(LN)是其最多见、最重要的表现之一。抗疟药是治疗SLE及LN的重要药物之一,临床应用日渐广泛。本文主要介绍抗疟药的作用机制、治疗SLE和LN的疗效及不良反应等。

关键词: 狼疮性肾炎, 羟氯喹, 抗疟药

Abstract:

Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease that affects various organs. Lupus nephritis(LN)is one of the most common, and most important manifestations of SLE. Antimalarial agents having numerous beneficial effects are part of the immunomodulatory regimen used to treat patients with SLE and LN. This Review will focus on the theorized mechanisms of action, the efficacy in patients with SLE and LN, and potential adverse effects of antimalarial agents.