DAMPs和肾脏疾病

肾脏病与透析肾移植杂志 ›› 2014, Vol. 23 ›› Issue (2): 163-167.

DAMPs和肾脏疾病

出版日期:2014-04-28 发布日期:2014-04-28

DAMPs and kidney diseases

Online:2014-04-28 Published:2014-04-28

摘要/Abstract

摘要：

摘要 DAMPs是机体受到损伤后释放的内源性预警信号，可以激活固有免疫系统，联系适应性免疫，介导无菌性炎症。近年来，DAMPs在肾脏疾病领域日益受到关注。为此，本文将对常见DAMPs、DAMPs受体、DAMPs与肾脏疾病的关系等就相关的研究作一综述。

关键词: 肾脏疾病, DAMPs , , 模式识别受体

Abstract:

ABSTRACT Danger-Associated Molecular Patterns (DAMPs) are the endogenous molecules released from injured or stimulated cells, which can cause innate immune response, and even a subsequent adaptive immunity, thereby playing a vital role in sterile inflammation. Accumulating evidences have shown that DAMPs is involved in the pathogenesis of nephropathies, thus being potential therapeutic targets for the treatment of kidney diseases. This review summarizes recent advances in understanding the roles of DAMPs in the development of kidney diseases.

Key words: kidney disease, DAMPs, PRR

何静| 施少林. DAMPs和肾脏疾病[J]. 肾脏病与透析肾移植杂志, 2014, 23(2): 163-167.

He Jing| Shi Shaolin. DAMPs and kidney diseases[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2014, 23(2): 163-167.

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