Abstract: The TAM (TYRO3,AXL,MER) receptor tyrosine kinases (RTKs) belongs to the RTKs subfamilies,playing pivotal roles in cell proliferation,survival,migration,efferocytosis,inflammation/immune regulation and platelet stabilization.Evidence based on animal models indicate that dysfunction of renal or systemic TAMRTKs may involve in pathogenesis of kidney diseases including Thy1 glomerulonephritis,diabetic nephropathy,antiglomerular basement membrane nephritis,unilateral ureteral obstruction,nephrotoxic serum nephritis,acute kidney injury and hypertensive renal damage.The increased levels of renal TAMRTKs and circulating secreted TAMRTKs in patients with lupus nephritis,diabetic nephropathy and chronic kidney disease (CKD) correlate with the disease severity,making TAMRTKs to be promising new biomarkers.TAMRTKs also participate in CKDinduced atherosclerosis and vascular calcification.This article reviews roles of TAMRTKs in kidney diseases.