ISSN 1006-298X      CN 32-1425/R

导航

肾脏病与透析肾移植杂志 ›› 2023, Vol. 32 ›› Issue (4): 353-357.DOI: 10.3969/j.issn.1006-298X.2023.04.012

• • 上一篇    下一篇

新型冠状病毒感染相关肾小球疾病

  

  • 出版日期:2023-08-28 发布日期:2023-08-30

Glomerular disease associated with COVID-19

  • Online:2023-08-28 Published:2023-08-30

摘要: 新型冠状病毒感染(COVID-19)可通过病毒的直接侵袭、内皮细胞损伤、免疫系统调节失衡和肾素-血管紧张素-醛固酮系统功能紊乱等多种机制造成组织器官损伤。尽管COVID-19以肺部损伤为主要表现,重症患者急性肾损伤的发生率高达50%,由其可能引发的肾小球疾病同样不容忽视。本文综述近3年文献报道的COVID-19相关肾小球疾病的临床表现、病理特征,并探究其引发肾脏损伤的潜在机制。


关键词: 新型冠状病毒感染, 足细胞损伤

Abstract: COVID-19 can cause tissue and organ damage through a variety of mechanisms, including direct viral invasion, endothelial cell damage, imbalance of immune system regulation, and dysfunction of the renin angiotensin aldosterone system (RAAS). Although COVID-19 is mainly characterized by lung injury, the incidence of acute kidney injury is as high as 50% in critically ill patients, the possible glomerular diseases caused by it should not be ignored. In this article, we review the clinical manifestations and pathologic features of COVID-19 associated glomerular diseases reported in literature in the past 3 years, and explore potential mechanisms of renal injury caused by COVID-19.


Key words: COVID-19, podocyte injury