关键词: 狼疮性肾炎,狼疮性肠炎,临床特征,预后

Abstract: Ｏｂｊｅｃｔｉｖｅ：To investigate  clinicpathological characteristics and  interrelation between lupus nephritis (LN) and lupus enteritis (LE).
Ｍｅｔｈｏｄｏｌｏｇｙ：A retrospective study was performed on patients presenting LE in LN from January 2010 to November 2019. Their clinicpathological characteristics and outcomes were analyzed. 
Ｒｅｓｕｌｔｓ：Of the 3 430 patients with LN,90 (26%) patients were diagnosed with LE. Both clinical and serology showed lupus activity,and the SLEDAI score was 1171±487 when LE occurred. The manifestations of LE were abdominal pain (800%),nausea and vomiting (678%),diarrhea (644%),and alimentary tract hemorrhage (67%). The majority of patients with abdominal CT prompt submucosal edema (679%),bowel wall thickening (790%),and intestinal cavity expansion (407%),ascites (567%),60% “target sign”. The hematologic (756%),lupus myocarditis (111%),and neurological involvement (44%) were observed. And 26 patients were hydronephrosis or hydroureters. Acute kidney injury,and nephrotic syndrome were found in 23 (256%),24 (267%) patients,respectively. The proportion of LE in lupus podocytopathy (143%),and LN class Ⅱ (118%) were higher than that in class V (26%) and proliferative LN (17%). 88 patients were improved after immunosuppressive therapy. With a median followup of 440 months,13 cases (144%) had LE recurrence. The 5 years patient and renal survival were 874% and 720%,respectively. And the 5 years renal survival was just 536% in proliferative LN. The renal survival rate in LE group was significantly lower than in control group. Cox multivariate analysis showed that time course of LN,renal insufficiency,cardiac insufficiency,and gastrointestinal bleeding were risk factors affecting  renal prognosis of patients with LN and LE
Ｃｏｎｃｌｕｓｉｏｎ：
LN patients with LE have strong renal and external organ activity,and LE is more common in nonproliferative LN. Their prognosis was poor,especially in patients with proliferative LN; early diagnosis and treatment of LE should be emphasized to improve prognosis.

Key words: lupus nephritis, lupus enteritis, clinical characteristics, prognosis