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肾脏病与透析肾移植杂志

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新型冠状病毒肺炎相关肾脏损伤研究进展

  

  • 出版日期:2020-10-28 发布日期:2020-10-30

Kidney injury in COVID-19

  • Online:2020-10-28 Published:2020-10-30

摘要: 新型冠状病毒肺炎(新冠肺炎)目前仍处于全球大流行阶段,虽然肺部损伤是新冠肺炎患者的主要临床表现,肾脏作为人体内稳态的重要调节器官被广泛关注。研究认为病毒直接作用,免疫紊乱与血栓炎症等多种因素均有可能导致肾脏损伤。但目前针对新冠肺炎与肾脏损伤的相关研究有限,新型冠状病毒与肾脏损伤的具体关系尚不明确。此外,在疫情大流行期间,透析人群与肾移植受者的感染风险显著增加,需要更加严谨、合理的临床管理和预防策略。本文就新冠肺炎相关肾脏损伤的研究进展进行综述,以进一步认识新冠肺炎和肾脏损伤的关系,了解肾脏领域需要关注和解决的问题。

关键词: 新型冠状病毒肺炎, 肾脏损伤, 透析, 肾移植

Abstract: Corona virus disease 2019 (COVID19) caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV2) has become a pandemic in the world.Although COVID19 is most well known for causing substantial respiratory pathology,it can also result in several extrapulmonary manifestations.The kidney is widely concerned as an important regulator of homeostasis in human body.Direct viral toxicity,dysregulation of  immune response,thromboinflammation and other factors may be related to kidney injury.However,studies on COVID19 leading to kidney injury are still limited,and the specific relationship between SARSCoV2 and kidney injury is still unclear.In addition,during the epidemic,risk of infection in kidney dialysis patients and renal transplant recipients increases,and more reasonable management and prevention are needed.In order to further understand the relationship of COVID19 and kidney injury,and the problems that need to be paid attention to and solved in the kidney field,this article reviews the research progress of kidney injury in COVID-19.