关键词: 阻塞性睡眠呼吸暂停低通气综合征, 慢性肾脏病, 发病机制

Abstract: The prevalence of obstructive sleep apnea hypopnea syndrome (OSAHS) has been increasing in recent years, and there have been an increasing number of clinical case reports of OSAHS associated with chronic kidney disease (CKD). More and more studies have shown that OSAHS and CKD influence each other. OSAHS can induce CKD through chronic intermittent hypoxia, oxidative stress, activation of renin-angiotensin-aldosterone system activity, and elevated blood pressure; and CKD can also contribute to the development of OSAHS through fluid overload, altered chemoreflex sensitivity, and uremia-induced neuropathy. This article systematically reviews the epidemiologic characteristics of OSAHS and CKD and elucidates the current state of research on the relationship between the two from a pathophysiologic point of view, with the goal of providing new ideas for subsequent research.

Key words: obstructive sleep apnea hypopnea syndrome, chronic kidney disease, pathogenesis