关键词: 新型冠状病毒肺炎, 肾功能损害, 预后分析

Abstract: Ｏｂｊｅｃｔｉｖｅ：The retrospective study aims to analyze associations between renal function impairment and prognosis in hospitalized cornoa virus disease 2019(COVID19) patients.Ｍｅｔｈｏｄｏｌｏｇｙ：A collection of 2 391 patients with COVID19 in Huoshenshan Hospital,including 1 263 cases of general type,1 044 cases of severe type,and 84 cases of critical type,were collected to analyze characteristic of renal dysfunction  and their impact on prognosis.Ｒｅｓｕｌｔｓ：The mortality rate for critical,severe and general groups was 512% (43/84),05% (5/1 044) and 0 respectively.Serum creatinine,urea nitrogen,cystatin C and uric acid were significantly higher in critical groups than in other groups,eGFR in critical group was significantly lower than that in the general and severe groups. The rate of proteinuria and hematuria was 31% (58/1 831) and 125% (229/1 831) respectively.The total  incidence of AKI was 43%,of which the general group was 08%,severe group was 44% and critical group was 524%. Multiple regression analysis showed that prognostic factors included disease severity,advanced age (>65),increased blood neutrophil count,lower lymphocyte count,elevated aspartate transaminase(AST) and creatiue kinaseMB(CKMB).The multiple regression analysis adjusting for extrarenal factors showed that factors were also the risk factors of poor prognosis,such as increased blood creatinine,elevated cystatin C,AKI and eGFR<60 ml/(min·173m2).Ｃｏｎｃｌｕｓｉｏｎ：AKI can occur in  COVID19 patients.The incidence of AKI increased with increasing severity. Multiple regression analysis showed that after adjusting for extrarenal factors,indicators of increased blood creatinine,elevated cystatin C,AKI and eGFR<60  ml/(min·173m2) have prognostic values.