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肾脏病与透析肾移植杂志

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肾脏疾病代谢组学研究的进展

  

  • 出版日期:2020-06-28 发布日期:2020-07-07

Recent advances of  metabolomics in kidney diseases

  • Online:2020-06-28 Published:2020-07-07

摘要: 随着核磁共振和质谱分析技术的普及,代谢组学应运而生。代谢组学不仅能够反映体内实时的生化过程,还可反映饮食、环境及肠道微生物等对代谢产物水平的影响。由于肾脏与代谢之间存在密切的联系,代谢组学技术在肾脏疾病分子标志物和分子机制的研究方面具有极大的潜能。本文将对肾脏疾病相关代谢组学研究进展作一综述。

关键词: 代谢组学, 肾脏疾病, 肠道微生物

Abstract: With the popularization of nuclear magnetic resonance spectroscopy and mass spectrometry,metabolomics emerged at the right moment.Metabolomics could provide information about the actual processes that are occurring within the body.Moreover,it could also reflect the effects of diet,environment,and gut microbiome on kidney diseases.Due to the close interactions between kidney and metabolism,metabolomics has enormous potential in the fields of nephrology for biomarkers and molecular mechanisms.In this article,we reviewed recent metabolomic findings relevant to kidney diseases.

Key words: metabolomics,kidney diseases, gut microbiome