肾脏病与透析肾移植杂志 ›› 2018, Vol. 27 ›› Issue (6): 585-588.DOI: 10.3969/j.issn.1006-298X.2018.06.019
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中年女性患者，确诊肺癌1年半，抗血管内皮生长因子（VEGF）药物治疗后出现水肿，大量蛋白尿和高血压，肾活检组织学为肾小球膜增生性病变伴系膜溶解和内皮细胞病变，同时伴有免疫球蛋白和补体沉积，结合临床，考虑抗VEGF药物肾损害合并免疫复合物相关性肾小球肾炎。
关键词: 肺癌, 抗血管内皮生长因子药物, 肾小球膜增生性病变, 肾活检
Abstract:
A 48yearold woman presented with edema，heave proteinuria and hypertension.The patient was diagnosed with lung cancer in 2017 and underwent chemotherapy and antivascular endothelial growth factor therapy.A renal biopsy showed membranoproliferative glomerulonephritis with mesangiolysis,and deposition of immunoglobulin and complement the final diagnosis was glomerular disease related to antiVEGF therapy with immune complex associated glomerulonephritis.
徐峰,曾彩虹. 抗血管内皮生长因子药物肾损害合并免疫复合物相关性肾小球肾炎[J]. 肾脏病与透析肾移植杂志, 2018, 27(6): 585-588.
XU Feng，ZENG Caihong. Kidney injury after antivascular endothelial growth factor therapy complicated with immune complex glomerulonephritis[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2018, 27(6): 585-588.
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http://www.njcndt.com/CN/Y2018/V27/I6/585
