关键词: 血液透析, 可溶性尿激酶型纤溶酶原激活物受体, 血管钙化, 心血管疾病

Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the associations between soluble urokinase plasminogen activator receptor (suPAR) and coronary aretery calcification and clinical outcomes in maintenance hemodialysis patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：A total of 99 adult hemodialysis patients were enrolled in this study. Plasma samples were analyzed for suPAR by ELISA and coronary aretery calcification  score  (CACS) was detected by MDCT. Occurrences of new onset cardiovascular events and allcause mortality were examined until 1st June 2016.The association of suPAR to CACS was evaluated by Bivariate and risk factors of mortality were identified with a multivariate COX proportional hazard model.
Ｒｅｓｕｌｔｓ：Of the 99 MHD patients, 91 (919%) had varying degrees of CAC. SuPAR was positively correlate with CAC Score using Spearman analysis（P=0001,r=0315）. In comparison with the CACS<100 group, suPAR was higher in the CACS≥100 group (P=0048). Quartiles of suPAR were employed as the cutoff point for subgroup analysis, the incidence of CVD and allcause mortality was much higher in the higher quartiles of suPAR. In the univariate COX regression analysis, higher suPAR is a risk factor of CVD and allcause mortality. In the COX proportional hazards model after adjustment for multifactors, suPAR remained an independent factor of CVD.
Ｃｏｎｃｌｕｓｉｏｎ：suPAR is associated with CACS core and show a clear, graded association with a higher risk for new onset cardiovascular disease in MHD patients.