Abstract:

MicroRNA(miR) is a kind of endogenous single strand RNA, which posttranscriptionally regulates gene expression in eukaryocyte. MiR30 family consists of 5 members, miR30a through miR30e. Previous studies revealed that miR30 played an important role in kidney development as well as renal injury. Mechanism study demonstrated that they could protect podocyte by reducing apoptosis and cytoskeleton damage via inhibiting p53,Notch1 and calcium/calcineurin pathways. Meanwhile, miR30e ameliorated interstitial fibrosis through regulating mitochondrial function in tubular epithelial cells. Clinical studies also suggested that urine miR30a5p could serve as a biomarker of adult FSGS and  primary nephrotic syndrome in children, which was correlated with activity of disease and therapeutic effect of glucocorticoids.