Abstract:

hypertension is a common clinical manifestation of chronic kidney disease, as well as a major risk factor for the progression of renal disease. Chronic kidney disease is associated with premature vascular aging, autonomic dysfunction and subclinical volume overload. The concommittent use of other agents that interfere with antihypertensive treatment is also very common in these patients, leading to an increased prevalence of resistant hypertension. Recently the Systolic Blood Pressure Intervention Trial provided new evidence of benefits of intensive hypertension control in cardiovascular disease. However, the effects of the lower blood pressure on the longterm renal outcome remain unclear. The optimal target blood pressure to reduce hypertensionrelated adverse in chronic kidney disease needs to be further explored in more large, and definitive clinical trials.