糖尿病肾病合并木糖醇相关草酸钙肾损伤

肾脏病与透析肾移植杂志 ›› 2016, Vol. 25 ›› Issue (2): 191-194.

糖尿病肾病合并木糖醇相关草酸钙肾损伤

出版日期:2016-04-28 发布日期:2016-05-04

Diabetic nephropathy complicated with acute calcium oxalate kidney injury

Online:2016-04-28 Published:2016-05-04

摘要/Abstract

摘要：

摘要 59岁男性，糖尿病20年，伴高血压、高尿酸，肾脏表现为蛋白尿2年，血肌酐升高2月，1月余前外院输注“木糖醇”后出现急性肾损伤。肾活检显示肾小球结节性病变，肾小管间质慢性病变合并急性病变，伴肾小管上皮细胞胞浆及管腔内大量草酸钙结晶。最终诊断为糖尿病肾病合并急性草酸钙肾病(木糖醇相关)。

关键词: 草酸钙肾病, 结晶, 木糖醇, 肾活检

Abstract:

ABSTRACT A 59 year-old man suffered from diabetes for 20 years. He had hypertension and hyperuricemia, and also had complications of diabetic nephropathy which presented with proteinuria, hypoalbuminemia, and renal insufficiency. One month ago, he received xylitol with a quotidian dose of 25g for 13 days, and then acute kidney injury occurred. A renal biopsy showed glomerular nodular lesions, and interstitial fibrosis and tubular atrophy. In addition, massive depositions of double refractive crystals located in the tubules of the renal cortex in the polarized light microscopy accompanied by necrosis of the tubular epithelium. The final diagnosis was acute calcium oxalate nephropathy superimposed on diabetic nephropathy.

Key words: calcium oxalate nephropathy, crysta, xylitol, renal biopsy

梁少姗|曾彩虹. 糖尿病肾病合并木糖醇相关草酸钙肾损伤[J]. 肾脏病与透析肾移植杂志, 2016, 25(2): 191-194.

LIANG Shaoshan|ZENG Caihong. Diabetic nephropathy complicated with acute calcium oxalate kidney injury[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2016, 25(2): 191-194.

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