关键词: 塌陷性肾小球病 , 发病机制 , HIV相关性塌陷性肾小球病 足细胞损伤

Abstract:

ABSTRACT  According to the Columbia classification, collapsing glomerulopathy (CG) is an morphologic variant of focal segmental glomerulosclerosis (FSGS) , characterized by segmental or global glomerular capillary loop collapse with marked proliferation and hypertrophy of overlying podocytes. Since the first case of CG was published in 1979, the CG is now becoming an important cause of ESRD because of the poorly understood of underlying mechanism and poor responders to standard therapies. Gratifyingly, the exciting progress has been made in research into the pathogenesis of CG during the past two decades. Recently, the researches have focused on the origin of proliferative podocytes and the underlying mechanism behind the phenomenon. In addtion to discovering susceptibility genes for CG and the growing awareness of the signaling pathways participate in podocytes injure provide important insights into the pathogenesis of CG. This review highlights the recent advances in research into the pathogenesis of CG .

Key words: Collapsing glomerulopathy , pathogenesis , HIVAN , podocytes injure