ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2026, Vol. 35 ›› Issue (1): 97-100.DOI: 10.3969/j.issn.1006-298X.2026.01.020

• 临床集锦 • 上一篇    

小剂量激素治疗白细胞趋化因子2型肾淀粉样变性合并膜性肾病

  

  • 出版日期:2026-02-27 发布日期:2026-02-27

Treatment of leukocyte cell-derived chemotaxin 2 amyloidosis nephropathy complicated with membranous nephropathy with low dose glucocorticoid

  • Online:2026-02-27 Published:2026-02-27

摘要: 中年女性患者,以肾病综合征起病,肾穿刺活检结果提示白细胞趋化因子 2 (LECT2) 型肾淀粉样变性合并 Ⅱ 期膜性肾病,予以厄贝沙坦氢氯噻嗪支持对症治疗后,疗效不佳。转入我院后,调取外院肾穿刺活检石蜡样本,行激光微切割质谱分析 (LMD-MS),排除其他类型肾淀粉样变性可能,加用小剂量激素,随访 24 周,尿蛋白持续部分缓解,水肿较前明显改善。

关键词: 白细胞趋化因子 2, 淀粉样变性, 膜性肾病, 激光微切割质谱分析

Abstract: A middle-aged female patient with nephrotic syndrome with renal biopsy indicated that leukocyte cell-derived chemotaxin 2 (LECT2) amyloidosis complicated with stage Ⅱ membranous nephropathy. The symptoms were not well controlled after the symptomatic treatment was supported by irbesartan and hydrochlorothiazide. After being transferred to our hospital, low-dose prednisone was added when other types of amyloidosis nephropathy were excluded by laser microdissection mass spectrometry (LMD-MS). After 24 weeks of follow-up, urinary protein was partially relieved and edema was significantly improved.

Key words: leukocyte cell-derived chemotaxin 2, amyloidosis, membranous nephropathy, laser microdissection and mass spectrometry