关键词: 昼夜节律紊乱, 生物钟, 慢性肾脏病, 生物钟疗法

Abstract: Circadian rhythm disorder can increase the risk of diseases including chronic kidney disease (CKD), cancers, diabetes, hypertension, neurological diseases and cardiovascular diseases. Although the treatment of CKD has made great progress,CKD remains a global public health problem and an important cause of cardiovascular death. Therefore, it is necessary to explore new treatments. As a major organ of the peripheral clock system, kidney participates in regulating the formation of circadian rhythms. This article reviews the association between circadian rhythm disruption and CKD, and related interventions such as circadian therapeutics, to provide new strategy for the prevention and treatment of CKD.

Key words: circadian rhythms disorder, circadian clock, chronic kidney disease, circadian therapeutics