肾小球滤过率公式在中国慢性肾脏病儿童中的应用

doi:10.3969/j.issn.1006-298X.2023.02.002

肾脏病与透析肾移植杂志 ›› 2023, Vol. 32 ›› Issue (2): 107-114.DOI: 10.3969/j.issn.1006-298X.2023.02.002

肾小球滤过率公式在中国慢性肾脏病儿童中的应用

陈楷柠, 杜悦

出版日期:2023-04-28 发布日期:2023-04-24

Glomerular filtration rate formula in Chinese children with chronic kidney disease

CHEN Kaining, DU Yue

Online:2023-04-28 Published:2023-04-24

摘要/Abstract

摘要： 目的：将国外学者提出的9种肾小球滤过率(GFR)评估公式与Tang等提出的2个中国儿童GFR评估公式进行对比,选择出适合慢性肾脏病(CKD)儿童的GFR评估公式。
方法：回顾性分析2011-01-01～2021-12-31于中国医科大学附属盛京医院小儿肾脏风湿免疫科住院的CKD患儿资料。以99mTc-DTPA肾动态显像测得的GFR(iGFR)为金标准,比较各公式估算的肾小球滤过率(eGFR)与iGFR之间的偏差、精确度、准确度;比较各公式对CKD评估的准确性。
结果：纳入CKD患儿949例,其中男性547例(58％)。男性和女性患儿中,不论青春期前后,均以Tang提出的中国儿童GFR评估公式2的准确度最高。男性患儿中,CKD 1期公式1准确性最高,CKD 2～4期公式2准确性最高,CKD 5期C-B公式准确性最高。在女性患儿中,CKD 1期公式1准确率最高,CKD 2～3期公式2准确性最高,CKD 4期C-G公式及Filler公式准确性较高,CKD 5期CKDEPICysC公式准确性最高;以iGFR<60 mL／(min·1.73m2)为 CKD诊断标准,公式2诊断CKD的准确性最高。
结论：推荐Tang提出的中国儿童GFR评估公式2作为中国CKD儿童评估GFR的首选。

关键词: 肾小球滤过率公式, 儿童慢性肾脏病, 肾小球滤过率

Abstract: Ｏｂｊｅｃｔｉｖｅ：To compare the 9 glomerular filtration rate (GFR) evaluation formulas proposed by foreign scholars with the 2 new GFR evaluation formulas for Chinese children proposed by Tang based on the data of 751 Chinese children with chronic kidney disease (CKD), and select the appropriate GFR evaluation formula for Chinese children with CKD.
Ｍｅｔｈｏｄｏｌｏｇｙ：The inpatient data of children with CKD in the Department of Pediatric Renal Rheumatology and Immunology of Shengjing Hospital of China Medical University from January 1, 2011 to December 31, 2021 were analyzed retrospectively. Take the GFR measured by 99mTcDTPA renal dynamic imaging (iGFR) as the gold standard, and compare the deviation, precision and accuracy between iGFR and eGFR estimated by each formula; Compare the accuracy of each formula for GFR evaluation.
Ｒｅｓｕｌｔｓ：949 children with CKD (547 males, 58％) were included. Among male and female children, regardless of puberty, the accuracy of GFR evaluation formula 2 for Chinese children proposed by Tang is the highest. Among male children, formula 1 of CKD 1 is the most accurate, formula 2 of CKD 2~4 is the most accurate, and formula C-B of CKD 5 is the most accurate; Among female children, the accuracy of CKD 1 formula 1 is the highest, CKD 2~3 formula 2 is the highest, CKD 4 C-G formula and Filler formula are the highest, and CKD 5 CKD-EPI-cysC formula is the highest; Taking iGFR<60 mL／(min·1.73m2) as the diagnostic standard of CKD, formula 2 has the highest accuracy in diagnosing CKD.
Ｃｏｎｃｌｕｓｉｏｎ：The GFR evaluation formula 2 for Chinese children proposed by Tang is recommended as the first GFR evaluation formula for Chinese CKD children.

Key words: glomerular filtration rate formula, chronic kidney disease in children, glomerular filtration rate

陈楷柠, 杜悦. 肾小球滤过率公式在中国慢性肾脏病儿童中的应用[J]. 肾脏病与透析肾移植杂志, 2023, 32(2): 107-114.

CHEN Kaining, DU Yue. Glomerular filtration rate formula in Chinese children with chronic kidney disease[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2023, 32(2): 107-114.

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ISSN 1006-298X CN 32-1425/R

肾小球滤过率公式在中国慢性肾脏病儿童中的应用

Glomerular filtration rate formula in Chinese children with chronic kidney disease

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