关键词: 抗中性粒细胞胞质抗体相关性肾小球肾炎, 肾脏风险评分, 肾血管病变评分, 肾脏预后

Abstract: Ｏｂｊｅｃｔｉｖｅ：To evaluate predictive value of the renal risk score (RRS) and renal vascular lesions (RVLs) score for renal prognosis in Antineutrophil cytoplasmic antibody-associated glomerulonephritis (AAGN).
Ｍｅｔｈｏｄｏｌｏｇｙ：Patients diagnosed with AAGN at the First Affiliated Hospital of Zhengzhou University from April 2014 to May 2021 were collected. RRS and RVLs score were calculated based on results of renal biopsy and analyzed for their relationship with clinicopathological feature and renal prognosis.
Ｒｅｓｕｌｔｓ：A total of 137 patients were enrolled, 38 patients progressed to end-stage kidney disease. Serum creatinine, dialysis dependence, and systolic blood pressure were significantly higher in the high RRS and severe RVLs groups than in the low RRS and without RVLs groups, respectively, and the estimated glomerular filtration rate and percentage of normal glomeruli were significantly lower than in the low RRS and without RVLs groups, respectively. Survival analysis showed that within the RRS group, the renal prognosis was worse in the high and moderate RRS groups than that in the low RRS group (P<0.001). Within the RVLs group, the renal prognosis was worse in the severe RVLs group than that in the moderate, mild, and without RVLs groups (P<0.001). ROC analysis showed that the area under the 3-year renal survival curve for RRS, RVLs score, and RRS combined with RVLs score were 0.860, 0.789, and 0.919, respectively. The predictive power of RRS and RVLs score was comparable, and the predictive power of RRS combined with RVLs score was better than that of RRS and RVLs score.
Ｃｏｎｃｌｕｓｉｏｎ：In AAGN, the predictive power of RRS combined with RVLs score for renal prognosis was better than either RRS or RVLs score, which may serve as a new predictor.

Key words: antineutrophil cytoplasmic antibody-associated glomerulonephritis, renal risk score, renal vascular lesions score, renal prognosis