CCL2／CCR2信号通路在慢性肾脏病中的研究进展

doi:10.3969/j.issn.1006-298X.2022.05.012

肾脏病与透析肾移植杂志 ›› 2022, Vol. 31 ›› Issue (5): 456-460.DOI: 10.3969/j.issn.1006-298X.2022.05.012

CCL2／CCR2信号通路在慢性肾脏病中的研究进展

出版日期:2022-10-28 发布日期:2022-10-22

CCL2／CCR2 signaling pathway in chronic kidney disease

Online:2022-10-28 Published:2022-10-22

摘要/Abstract

摘要： 慢性肾脏病(CKD)是一类肾脏结构和功能进行性恶化或不可逆损伤的慢性疾病,研究发现趋化因子CCL2及其受体CCR2参与CKD的发生发展,靶向CCL2／CCR2信号通路已逐渐成为CKD治疗领域的研究热点。本文围绕CCL2／CCR2信号通路在CKD中的作用和机制进行综述,以期进一步阐明CKD的发病机制,为以CCL2／CCR2为靶点的免疫治疗提供新的研究依据。

关键词: 慢性肾脏病, 趋化因子, CCL2, CCR2

Abstract: Chronic kidney disease (CKD) is a chronic disease with progressive deterioration or irreversible damage to renal structure and function. Chemokine CCL2 and its receptor CCR2 have been reported to participate in the occurrence and development of CKD in recent studies, and targeting CCL2／CCR2 signaling pathway has gradually become a research hotspot in the treatment of CKD. In this review, we discuss the role and mechanism of CCL2／CCR2 signaling pathway in CKD to further clarify the pathogenesis of CKD and provide new research evidence for immunotherapy targeting CCL2／CCR2.

Key words: chronic kidney disease, chemokines, CCL2, CCR2

余霞霞, 沈娱汀, 岳昌武, 陈丽华. CCL2／CCR2信号通路在慢性肾脏病中的研究进展[J]. 肾脏病与透析肾移植杂志, 2022, 31(5): 456-460.

YU Xiaxia, SHEN Yuting, YUE Changwu, CHEN Lihua. CCL2／CCR2 signaling pathway in chronic kidney disease[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2022, 31(5): 456-460.

ISSN 1006-298X CN 32-1425/R

CCL2／CCR2信号通路在慢性肾脏病中的研究进展

CCL2／CCR2 signaling pathway in chronic kidney disease

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