p300／CBP在肾脏纤维化的作用和机制

doi:10.3969/j.issn.1006-298X.2022.05.013

肾脏病与透析肾移植杂志 ›› 2022, Vol. 31 ›› Issue (5): 461-464.DOI: 10.3969/j.issn.1006-298X.2022.05.013

p300／CBP在肾脏纤维化的作用和机制

出版日期:2022-10-28 发布日期:2022-10-22

The role and mechanism of p300／CBP in renal fibrosis

Online:2022-10-28 Published:2022-10-22

摘要/Abstract

摘要： 肾脏纤维化是各种病因引起的慢性肾脏病的主要病理改变,常进展至终末期肾病。组蛋白乙酰转移酶(HATs)介导的表观遗传调控在肾脏纤维化的发生发展中发挥重要作用。由高度同源的腺病毒E1A 相关的300 kD 蛋白(p300)和环磷酸腺苷反应元件结合蛋白(CREB)的结合蛋白(CBP)组成的p300／CBP 家族是HATs家族主要成员之一。本文总结了目前关于p300／CBP的结构、功能及其在肾脏纤维化中的作用和机制。旨在对肾脏纤维化的防治提供新的靶点和思路。

关键词: 组蛋白乙酰转移酶, p300／CBP, 肾脏纤维化

Abstract: ＴRenal fibrosis is the main pathological change of chronic kidney disease with various causes. It has been found that histone acetyltransferases (HATs) mediated epigenetic modification was tightly associated with the occurrence and development of renal fibrosis. The p300／CBP family consisting of the highly homologous adenovirus E1Aassociated 300 kDa protein (p300) and cAMP responsive element binding protein (CREB) binding protein (CBP) is one of the major members of the HATs families. This paper reviewed the structure, function, and the role of p300／CBP in renal fibrosis, attempting to provide new targets and ideas for the prevention and treatment of renal fibrosis.

Key words: histone acetyltransferases, p300／CBP, renal fibrosis

王艳哲, 吴明, 叶朝阳. p300／CBP在肾脏纤维化的作用和机制[J]. 肾脏病与透析肾移植杂志, 2022, 31(5): 461-464.

WANG Yanzhe, WU Ming, YE Chaoyang. The role and mechanism of p300／CBP in renal fibrosis[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2022, 31(5): 461-464.

ISSN 1006-298X CN 32-1425/R

p300／CBP在肾脏纤维化的作用和机制

The role and mechanism of p300／CBP in renal fibrosis

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