关键词: 急性肾损伤, 铁死亡, 谷胱甘肽过氧化物酶4, 脂质过氧化

Abstract: Acute kidney injury (AKI)has a rapid onset, but there is no early and sensitive indicator for dynamic monitoring of kidney function. Studies have found ferroptosis occured in various AKI models, and specific proteins and genes involved in ferroptosis are expected to be predictors of the occurrence and development of AKI. Ferroptosis is closely related to the metabolism of iron, amino acids and lipids, and it participates in development of AKI through pathological processes such as inflammation, endoplasmic reticulum stress and autophagy. Studies have confirmed that many kinds of drugs targeting on ferroptosis have achieved good efficacy in the treatment of AKI. This article reviews the mechanism of ferroptosis involved in development of AKI and the latest research progress of drugs for treatment of ferroptosis.

Key words: acute kidney injury, ferroptosis, glutathione peroxidase 4, lipid peroxidation