Abstract:

Acute kidney injury (AKI) is a common complication in critically ill patients.Although many drugs to prevent and treat AKI have shown benefits in animal models,no specific agent has been shown to benefit AKI in humans.Moreover,despite remarkable advances in dialysis techniques,dialysisrequiring severe AKI is still associated with an unacceptably high mortality rate.Thus,focusing only on kidney damage and loss of renal function has not been sufficient to improve outcomes of patients with AKI.Recent data from basic and clinical research have begun to elucidate complex organ interactions in AKI between kidney and distant organs,including heart,lung,spleen,brain,liver,and gut.This review serves to update the topic of organ cross talk in AKI and focuses on potential therapeutic targets to improve patient outcomes during AKIassociated multiple organ failure.

Key words: acute kidney injury, distant organs, therapeutic targets