关键词: 血清胱抑素, 多发性软组织, 急性肾损伤

Abstract:

ABSTRACT    Objective: To investigate the early prediction and diagnostic value of serum cystatin C (CysC) for acute kidney injury (AKI) in patients with adult multiple soft tissue contusion. Methodology: blood and urine samples of hospitalizing patients with adult multiple soft tissue contusion were prospectively collected. Ten cases of AKI were selected and their CysC, SCr and eGFR were measured; 10 cases of non-AKI patients with similar clinical data were selected as control. Dynamic changes of CysC and SCr were monitored for both groups after admission. Receiver operating characteristic (ROC) curve was used to evaluate the accuracy of CysC-dependent diagnosis. AKI was defined as ≥50% increase of SCr level compared to baseline value. Results: 20 cases had an average age of 29.0 ± 8.76, and a baseline SCr level of (68.9± 21.5)?mol/L. The clinical indicators of the two groups had no significant difference. In AKI group, their urinary and blood biological markers were elevated at different time points after admission. When the blood CysC was measured 10hrs after hospitalization, and the diagnostic cut-off point at 1.36 was set, it would have sensitivity of 0.72 and a specificity of 0.93. Conclusion: When AKI occurs in adult soft tissue contusion patients, the blood and urinary biomarkers will be significantly increased at different time points. This change is earlier than that of SCr and can be used for diagnosis of AKI with high accuracy. It can be used as an early diagnostic marker for AKI in adult multiple soft tissue contusion patients.