ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2012, Vol. 21 ›› Issue (4): 363-365.

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慢性肾脏疾病与“肠肾综合征”

  

  • 出版日期:2012-08-28 发布日期:2012-09-03

Intestinal-Renal Syndrome: Conception, Knowledge and Enlightenment

  • Online:2012-08-28 Published:2012-09-03

摘要:

摘 要 基于尿毒症血液透析时肠道一过性缺血导致肠道通透性增高、肠道菌群移位,从而诱发尿毒症患者体内多种病理改变的现象,在2011年国际透析大会上,Ritz首次提出“肠肾综合征”的概念,但未给出明确定义“肠肾综合征”。本文通过综述肠肾间相互影响及通过肠道途径治疗肾脏病,阐述了“肠肾综合征”的合理性,并确立“肠肾综合征”的概念——肠道和肾脏中一个器官发生改变时对另一个器官产生不利影响,能互为因果引起和(或)相互加重,藉此希望通过引入“肠肾综合征”,重新审视肠道和肾脏疾病的关联性,以肠道为靶点,提高慢性肾脏疾病的诊疗效果。

关键词: 肠肾综合征  , 终末期肾病  , 菌群

Abstract:

ABSTRACT   The term of ‘intestinal-renal syndrome’ was proposed by Ritz in 13th International Conference on Dialysis, Advances in CKD 2011. However, Ritz didn’t give a definition of ‘intestinal-renal syndrome’ and he was uncertain about its reality. To characterize the ‘intestinal-renal syndrome’, this paper summarized the relationship between gut and kidney in normal and disease status, and briefly reviewed what is currently known about its treatment options.

Key words: intestinal-renal syndrome  , end stage renal disease  , microbiome