关键词: 急性肾损伤, 过氧化物酶体增殖物激活受体&gamma, 辅激活物1-&alpha, 线粒体, 肾小管上皮细胞

Abstract:

Acute kidney injury (AKI) is a common critical disease.Mitochondrial injury and dysfunction of renal tubule epithelial cells (RTECs) induced by several causes is main pathophysiological change in AKI.Peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) is a nuclear transcriptional coactivator,which acts as a “master regulator” in maintaining mitochondrial homeostasis.Downregulation of PGC1α was found to mediate mitochondrial damage and lipid metabolism disorder in RTECs,leading to occurrence and development of AKI.Therefore,PGC1α may be a new target for AKI therapy.This review summarizes the current progress on acute kidney injury and PGC1α.

Key words: acute kidney injury, peroxisome proliferator-activated receptor &gamma, coactivator 1-α, mitochondrion, renal tubule epithelial cells