Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the distribution and evolution trend of biopsy proven kidney disease.
Ｍｅｔｈｏｄｏｌｏｇｙ：Cases in the Renal Biopsy Registry of National Clinical Research Centre of Kidney Diseases in Jinling Hospital from 1st January 2003 to 31st December 2014 were enrolled. We analyzed the distribution and compared with data from 1979 to 2002.
Ｒｅｓｕｌｔｓ：In total,40 759 cases of renal biopsy were analyzed. The proportion of patients over 60 years mounted up from 560% to 989%. The comparison of spectrum in 19792002 and 20032014 showed that primary glomerulonephritis(PGN) decreased while secondary glomerulonephritis(SGN) increased. IgA nephropathy(IgAN) was the most common type of PGN. The proportion of MN in PGN was roughly double that of MN in 1979～2002, and the biggest increase was in 14～24 years group. Among SGN there were immunemediated diseases (5920%) and tumorassociated or metabolic diseases (3709%). The proportion of tumorassociated or metabolic diseases associated SGN such as DN,renal amyloidosis,hypertensive nephrosclerosis and monoclonal immunoglobulin deposition disease(MIDD) in SGN rose.
Ｃｏｎｃｌｕｓｉｏｎ：
PGN remained the predominant kidney disease in China,among which IgAN was the most common type. The proportion of MN increased significantly,especially in adolescent patients. The proportion of DN,renal amyloidosis,hypertensive nephrosclerosis and MIDD in SGN rose. The changing spectrum may provide reference and basis for clinical diagnosis,prevention and epidemiological survey.

Key words: epidemiology, spectrum of kidney disease, renal biopsy