Abstract: Secondary hyperoxaluria is a metabolic disease characterized by excessive urinary oxalate excretion and calcium oxalate crystal deposition,whose pathogenic factors include excessive intake of oxalate foods and oxalate precursors,increased intestinal absorption of oxalate,and the alteration of intestinal flora. The current diagnostic methods mainly include urine and plasma oxalic acid levels,imaging examination,and renal biopsy. Treatment options include etiological therapy,conservative measures,dialysis and organ transplantation. In addition,there are other potential treatments that need to be explored.