Abstract: Ｏｂｊｅｃｔｉｖｅ：To analyze  characteristics and changes of renal histopathological diagnosis of childrens renal diseases in the Second Affiliated Hospital of Harbin Medical University.
Ｍｅｔｈｏｄｏｌｏｇｙ：Data of children with renal diseases who underwent renal biopsy in our hospital from 2002 to 2019 were collected and analyzed retrospectively. The subjects were divided into the first stage (20022010) and the second stage (20112019) for crosssectional comparative analysis.
Ｒｅｓｕｌｔｓ：(1) General situation:785 children with renal biopsy were included in the study,ratio of male and female was 143∶1,ratio of children aged 06,712 and 1318 years accounted for 866% (68 cases),3338% (262 cases) and 5796% (455 cases),respectively. (2) Pathological types:primary glomerular diseases accounted for 7694%,secondary glomerular diseases accounted for 2114%,hereditary and congenital kidney diseases accounted for 076%,renal tubulointerstitial diseases accounted for 115%. (3) Pathological spectrum change:mild pathological glomerulonephritis is the most common primary glomerulonephritis in the first stage,IgA nephropathy is the most common primary glomerulonephritis in the second stageThe proportion of lupus nephritis(LN) and HenochSchonlein purpura nephritis(HSPN) increased from 086% and 431% in the first stage,and increased to 759% and 1844% in the second stage,respectively.
Ｃｏｎｃｌｕｓｉｏｎ：Primary glomerular disease is still the main renal disease of children in this center. IgA nephropathy has become the most common primary glomerular disease in recent years,HSPN and LN are the main pathological types of secondary glomerular diseases.