Abstract:

Abstract A 38-year-old woman presented with arthralgia, fever and edema. Laboratory investigations revealed proteinuria, hematuria, elevated serum creatinine and anemia. Serum immunological examination showed positive antinuclear antibodies and low levels of complement 3. Monoclonal λ light chain was detected by serum immunofixation electrophoresis. Heart ultrasound examination showed the interventricular septal thickness 18mm. Renal biopsy showed AL amyloidosis, the biopsies of skin and bone marrow also exhibited amyloidosis. The final diagnosis was autoimmune disease coinciding with primary systemic amyloidosis with kidney, skin, heart and bone marrow involved.

Key words: autoimmune disease, AL amyloidosis, renal biopsy