Abstract: Renal fibrosis is a common outcome of various causes leading to the development of chronic kidney disease （CKD） to end-stage renal disease. It's crucial for the treatment of CKD patients to clarify the molecular mechanisms of renal fibrosis. There is a layer of polysaccharide protein complex （also called glycocalyx） on the endothelial cell surface，which constitutes the basic barrier between the blood and the vessel wall. Recent studies have shown that the glycocalyx degradation plays an important role in promoting renal fibrosis. This review will discuss the research progress on the mechanisms of glycocalyx involved in renal interstitial fibrosis and may provide new therapeutic strategies for CKD.

Key words: chronic kidney disease, renal fibrosis, glycocalyx