ISSN 1006-298X      CN 32-1425/R

Chinese Journal of Nephrology, Dialysis & Transplantation ›› 2023, Vol. 32 ›› Issue (2): 107-114.DOI: 10.3969/j.issn.1006-298X.2023.02.002

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Glomerular filtration rate formula in Chinese children with chronic kidney disease

CHEN Kaining, DU Yue   

  • Online:2023-04-28 Published:2023-04-24

Abstract: Objective:To compare the 9 glomerular filtration rate (GFR) evaluation formulas proposed by foreign scholars with the 2 new GFR evaluation formulas for Chinese children proposed by Tang based on the data of 751 Chinese children with chronic kidney disease (CKD), and select the appropriate GFR evaluation formula for Chinese children with CKD.
Methodology:The inpatient data of children with CKD in the Department of Pediatric Renal Rheumatology and Immunology of Shengjing Hospital of China Medical University from January 1, 2011 to December 31, 2021 were analyzed retrospectively. Take the GFR measured by 99mTcDTPA renal dynamic imaging (iGFR) as the gold standard, and compare the deviation, precision and accuracy between iGFR and eGFR estimated by each formula; Compare the accuracy of each formula for GFR evaluation.
Results:949 children with CKD (547 males, 58%) were included. Among male and female children, regardless of puberty, the accuracy of GFR evaluation formula 2 for Chinese children proposed by Tang is the highest. Among male children, formula 1 of CKD 1 is the most accurate, formula 2 of CKD 2~4 is the most accurate, and formula C-B of CKD 5 is the most accurate; Among female children, the accuracy of CKD 1 formula 1 is the highest, CKD 2~3 formula 2 is the highest, CKD 4 C-G formula and Filler formula are the highest, and CKD 5 CKD-EPI-cysC formula is the highest; Taking iGFR<60 mL/(min·1.73m2) as the diagnostic standard of CKD, formula 2 has the highest accuracy in diagnosing CKD.
Conclusion:The GFR evaluation formula 2 for Chinese children proposed by Tang is recommended as the first GFR evaluation formula for Chinese CKD children.


Key words: glomerular filtration rate formula, chronic kidney disease in children, glomerular filtration rate