Abstract: Ｏｂｊｅｃｔｉｖｅ：This retrospective study was to evaluate the clinical characteristics and prognosis of chronic kidney disease (CKD) patients complicated with novel coronavirus pneumonia (NCP).
Ｍｅｔｈｏｄｏｌｏｇｙ：We retrospectively analyzed the clinical and imaging features before and after coronavirus disease 2019 (COVID-19) of CKD patients complicated with NCP who were admitted to the National Clinical Research Center of Kidney Diseases, Jinling Hospital from December 2022 to June 2023.
Ｒｅｓｕｌｔｓ：Among the 72 CKD patients with NCP, the median age at COVID19 was 64 (39, 76) years old, and the median duration of CKD course was 36 (7, 120) months. The top four original diseases for CKD were diabetic nephropathy (22.22％), lupus nephritis (12.50％), membranous nephropathy (9.72％) and ANCA associated glomerulonephritis (9.72％), and the coverage rate of COVID-19 vaccine was 18.06％. 51.39％ of NCP were medium, 20.83％ were severe and 27.78％ were critical. The in-hospital mortality rate was 19.44％. The inflammatory index, proportion of fungal infection, heart failure, hepatic injury, and pneumothorax in the death group were higher than those in the survival group, and the lymphocyte subsets were lower than those in the survival group (P<0.05). Multivariate COX model showed that age, lactic dehydrogenase, CD4+T lymphpocyte and C-reactive protein during COVID-19 were independent risk factors for death in CKD patients complicated with NCP.
Ｃｏｎｃｌｕｓｉｏｎ：CKD patients with NCP have a high proportion of DN, a low vaccination rate and more concomitant diseases. Patients with advanced age, hypoxia, immunodeficiency and strong inflammatory response have a poor prognosis. Coinfections or superinfections of fungus and multiple organ failure are common during NCP treatment.

Key words: chronic kidney disease, COVID-19, survival rate, risk factors