Abstract: Lysosomes play a crucial role in the degradation and recycling of cellular waste. Misfolded proteins, pathogens, and damaged organelles are transported to the lysosomes for degradation. Additionally, they serve as a central signaling hub for sensing and coordinating cellular metabolism, immune responses, signal transduction, and plasma membrane repair. Lysosomal dysfunction can lead to the accumulation of substrate within the lysosomes, giving rise to lysosomal-related diseases. Kidney cells are rich in lysosomes and previous studies have shown that abnormalities in lysosomal structure or dysfunction in kidney cells are associated with various kidney diseases. This article describes the roles of lysosomes and reviews recent studies concerning the involvement of lysosomal homeostasis disruption in kidney diseases.

Key words: lysosome, kidney diseases, podocyte, renal tubular epithelial cell