Abstract: Membranous nephropathy (MN) is a common glomerular disease mediated by immune complexes(IC), and in situ IC deposit may be one of its major pathogenesis. The antigens and autoantibodies of MN and their significance of clinical are important parts of this field. A series of target antigens represented by Mtype phospholipase A2 receptor (PLA2R) and type 1 thrombospondin 7A domain (THSD7A) have been found, which is a continuous research achievement for decades. Due to the development of technology, the exploration of unknown target antigens can go further. Clinical manifestations and prognosis varying as different antigens or autoantibody titers of MN patients. Target antigens can be used as the classification of MN, which provides a basis for diagnosis and treatment,has a certain clinical significance.

Key words: membranous nephropathy, antigen, autoantibody