Abstract: Systemic lupus erythematosus (SLE) is an autoimmune disease with multiple system involvement.The pathogenesis of SLE is characterized by  loss of B cell selftolerance to autoantigen  production of autoantibodies.Currently,the main choice in treating SLE are  glucocorticoids,cytotoxic agents and calcineurin inhibitors.However,there are still some patients with poor response to treatment or recurrence.In recent years,B cell clearance specifically has gradually become an important strategy and research field in SLE treatment.The feasibility and prospects of this strategy is further comfirmed by the clinical expeience of rituximabIn this review,we will discuss the role of B cell and the current situation of B cell depletion stategy in SLE.The feasibility of Chimeric antigen receptorT cell  (CART cell) therapy  in SLE will be further explored.