Abstract:

A 77yearold male,presented as erythrocytosis,leukocytosis and thrombocytosis,splenomegaly,and an increased serum lactate dehydrogenase.The JAK2 V617F point mutation was detected.Bone marrow biopsy showed that myelofibrosis grading 1 and a proportion of plasma cells <10%.A κIgM monoclonal spike was found by immunofixation electrophoresis.Serum cryoglobulin was 89915 mg/L.He had a moderate proteinuria and normal renal function.Renal biopsy showed glomerular mesangial hypercellularity and segmental sclerosis.The final diagnosis was coexistence of myeloproliferative neoplasm and cryoglobulinemia.

Key words: myeloproliferative neoplasm, cryoglobulinemia, renal biopsy