Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigate the role of residual renal function (RRF) status in calculating the individualized peritoneal dialysis volume (PDV).
Ｍｅｔｈｏｄｏｌｏｇｙ：Measurement has been made for 5 476 times in 557 patients with peritoneal dialysis who were followed up every 3 to 6 month, and all measurement was divided into four groups according to residual glomerular filtration rate (rGFR): group A<2; group B 2~4; group C 4~6; and group D>6 ml/(min·173m2). The changes of dialysis parameters,  biochemical indicators and cardiac parameters of each group were investigated.
Ｒｅｓｕｌｔｓ：PDV,PDV of unit BMI (PDV/BMI), PDV of unit BSA (PDV/BSA),urine volume (UV), Kt/V urea, weekly Ccr (WCcr), nPCR, Alb, Hb, serum phosphorus were significantly different (P=0000) in group A, B, C and D. Left ventricular mass index (LVMI), cardiothoracic ratio (CTR) were significantly higher in group A than that in group B, C, D (P=0.000), and LVEF was significantly lower in group A than that in group B, C, D (P=0000). All measurements was divided into two groups according to peritoneal dialysis adequacy: group adequacy, Kt/V urea≥17 or WCcr≥50 (L/w), and in adequacy, Kt/V urea<17 and WCcr<50 (L/w). With measurement for 5 476 times, the majority of patients have been dialyzed adequately, while only 1 301 times have been dialyzed inadequately, covering 238%. There were significant differences rGFR，as well as  PDV,  PDV/BMI  and PDV/BSA between group inadequacy and adequacy (P=0000). Pearson correlation analysis showed that there was a linear correlation between rGFR and PDV/BMI in the state of adequate dialysis, and being formulated as follows: PDV/BMI=3237-1015rGFR (r=-0615,P=0000). Therefore, the formula for calculating individual PDV of PD patients was got as follows: PDV (mL/d)=(3237-1015rGFR)×BMI.
Ｃｏｎｃｌｕｓｉｏｎ：
Calculating dialysis dose based on RRF and BMI, not only achieve the goal of personalized dialysis, but also exert the advantages of RRF in PD to the maximum and improve the quality of dialysis.

Key words: peritoneal dialysis, dialysis adequacy, residual renal function, body mass index