Abstract:

Ｏｂｊｅｃｔｉｖｅ：To evaluate the clinical characteristics and risk factors of primary nephrotic syndrome(PNS) patients with severe infections.
Ｍｅｔｈｏｄｏｌｏｇｙ：Medical charts of PNS patients administrated during June 2012 to June 2017 with infections were systematically reviewed.
Ｒｅｓｕｌｔｓ：187 patients were enrolled in this retrospective study with 53(283%) developed critical infections and 134(717%) developed severe infections.The commonest infection site was pulmonary (5455%),followed by skin and soft tissue(2941%).Critical infections mainly resulted from opportunistic infections such as Pneumocystis,invasive Aspergillus,Acinetobacter Bauman and others.Low CD4+T cell count and 2～4 months of immunosuppressive therapy were independent risk factors for critical infections with PNS.Low mean arterial pressure and low platelet count indicated worse outcome.
Ｃｏｎｃｌｕｓｉｏｎ：These data indicated that pulmonary infection was the major infection in PNS patients and an approximately 3 months course of immunosuppressive therapy was a high risk period of critical infections. Lower CD4+T cell count was an independent risk factor for critical infections in PNS patients.Lower mean arterial pressure and lower platelet count indicated worse outcome.

Key words: nephrotic syndrome, infection, pulmonary infection, CD4+T cell, prognosis