Abstract:

ABSTRACT A 59 year-old man suffered from diabetes for 20 years. He had hypertension and hyperuricemia, and also had complications of diabetic nephropathy which presented with proteinuria, hypoalbuminemia, and renal insufficiency. One month ago, he received xylitol with a quotidian dose of 25g for 13 days, and then acute kidney injury occurred. A renal biopsy showed glomerular nodular lesions, and interstitial fibrosis and tubular atrophy. In addition, massive depositions of double refractive crystals located in the tubules of the renal cortex in the polarized light microscopy accompanied by necrosis of the tubular epithelium. The final diagnosis was acute calcium oxalate nephropathy superimposed on diabetic nephropathy.

Key words: calcium oxalate nephropathy, crysta, xylitol, renal biopsy