Abstract: Objective:To investigate the clinical characteristics， complications and prognosis of children with end- stage kidney disease （ESKD）undergoing peritoneal dialysis （PD）.    Methodology:The data of ESKD children who received PD and were followed in the  International  Pediatric  Dialysis  Network， IPDN-China  from June 2016 to  June 2024 in Henan Children＇s Hospital were  retrospectively  analyzed.    Results:Among  the 74 children， there  were 50 males  and 24 females， with an age range of 9 months to 16 years and 9 months.  The median age at the start of PD was 9 years and 4 months.The estimated glomerular filtration rate （eGFR）at the time of initiation of PD was 10.6±4.3 mL/（min·1.73m2 ）. The causes of ESKD included glomerular disease in 39 cases (52.70%） and congenital genetic metabolic diseases in 35 cases (47.30%）. Genetic testing was  performed  in 42  children， with  positive  results  in 30  cases  （71.43%）.  As  of  June  2024，  the  average duration of PD was  12.12  months.  97.30%  of  the  children  underwent  automated  peritoneal  dialysis  （APD），  and  2.70% underwent continuous ambulatory peritoneal dialysis （CAPD）. The average peritonitis rate was 1 episode per 26.9 treatment months. The urea  clearance  index  （Kt/V） was  3.1  ±  0.7  per  week.  Common  complications  included  hyperphosphatemia

（77.03%），  anemia   （67.57%），  left   ventricular   hypertrophy   （43.24%），  hypertension   （37.84%），  and   secondary hyperparathyroidism （36.49%）.  At  the  end  of  follow-up，  58  children  （78.38%） had  discontinued  PD.  The  reasons  for discontinuation included kidney transplantation in 56 cases (96.55%）， loss to follow-up in 1 case (1.72%）， and death in 1 case （1.72%）.  Currently，  16  children  are  still  undergoing  PD.     Conclusion: APD  has  become  an  important  alternative treatment for ESKD children， effectively prolonging life and creating conditions for kidney transplantation.

Key words: children, end-stage , kidney , disease, glomerular , disease, hyperphosphatemia, automated , peritoneal dialysis, International Pediatric Dialysis