Abstract:

RNA modification is a chemical  modification that  occurs  at  different  atoms  of  a  base, and more  than 170 modifications have been identified on RNA to date. A growing body of research has shown that RNA modification plays an indispensable role in the occurrence, development and prognosis of kidney disease.  A comprehensive understanding of RNA modification in kidney disease can help us understand the pathogenesis and prognosis of kidney disease.  This article summarizes  basic   concept   and   regulatory   role   of   four   common   RNA   modifications:   N6⁃methyladenosine   (m6A ) modification, 5⁃methylcytidine (m5C)  modification, adenosine  to  inosine  (A⁃to⁃I)  editing,  and  pseudouridylation(Ψ), aiming to provide reference for clinical and basic research.

Key words:  RNA  , modification     , N6?methyladenosine     , 5?methylcytidine     , adenosine  , to   inosine  , editing pseudouridylation kidney disease