Abstract: Ｏｂｊｅｃｔｉｖｅ：To observe pharmacokinetic features and influencing factors of entericcoated mycophenolate sodium (ECMPS)in renal allograft recipients.
Ｍｅｔｈｏｄｏｌｏｇｙ：sixtyseven kidney transplant recipients treated with ECMPS in combination with tacrolimus and prednisone were enrolled and divided into negative proteinuria (negative)group and proteinuria group according to 24hour quantitative of urine protein.Plasma mycophenolic acid (MPA) concentrations were determined by EMIT method at premedcation, 05, 1, 15,2,4,6,8,10 and 12 hours (C05, C1, C15, C2, C4, C6, C8, C10 and C12) after oral administration.
Ｒｅｓｕｌｔｓ：There were significant differences among serum creatinine (SCr),blood urea nitrogen (BUN), estimated glomerular filtration rate (eGFR), serum albumin (Alb), hemoglobin (Hb) between the two groups. The value of C0 and MPAAUC0～12h in proteinuria group was significantly higher than that of negative group［(486±234) mg／L vs (356±189) mg／L,P=0014), (6616±2708) mg·h／L vs (5881±2048) mg·h／L,P=0021)］.SCr was positively correlated with MPAAUC0～12h, while Hb,Alb and eGFR were negatively correlated with MPAAUC0～12h. The MPAAUC0～12h in the high eposure group with proteinuria was 9368 mg.h／L, which was significantly higher than the negative group with 8169 mg.h／L(P=0026). Hb level of MPA high eposure recipients was lower than that of low eposure group and target eposure group (P=0029), while SCr level was higher than that of the other two groups (P=0014).
Ｃｏｎｃｌｕｓｉｏｎ：
There was a significant correlation between renal allograft function, Hb, Alb and MPAAUC0～12h. Postoperativeproteinuria increased the risk of MPA high eposure in the renal allograft recipients.

Key words: proteinuria, kidney transplantation, enteric-coated mycophenolate sodium, estimated glomerular filtration rate