Abstract:

Ｏｂｊｅｃｔｉｖｅ：To investigated the clinical and neuroimaging features of patients with primary nephritic syndrome who developed reversible posterior leukoencephalophathy syndrome (PRLS), and to characterize the risk factors of PRLS in these patients.
Ｍｅｔｈｏｄｏｌｏｇｙ：The clinical and neuroimaging features of seven patients with PRLS were analyzed retrospectively.
Ｒｅｓｕｌｔｓ：They were 4 males and 3 females with an average age of (127±353) years old. The mean urine protein was (41±54) g/24h, and serum albumin was (218±27) g/L. Among them, 4 cases accompanied with acute kidney injury, 4 cases had electrolyte disorders, and 4 cases complicated with infection. 4 cases received renal biopsy, and the histological diagnosis was minimal change disease in 2 cases, and membranous nephropathy in other 2 cases. 3 patients had normal blood pressure, and the other 4 cases have mild hypertension. 6 cases manifested as tonicclonic seizures, and one case showed as complex partial seizure. 5 patients underwent CT examination, 4 cases showed bilateral patchy low density foci, and one showed no abnormity. For the first MRI scan, all the 7 cases showed bilateral symmetry abnormal signal on the cerebral cortex of frontal lobe, parietal lobe and occipital lobe, with low signal on T1WI, high signal on T2WI.
Ｃｏｎｃｌｕｓｉｏｎ：Our data suggested that the idiopathic nephritic syndrome patients with younger or children, with high pressure, with electrolyte disturbance, with elevated serum creatinine, and with infection are more susceptible to PRLS.