早期纠正慢性肾脏病患者酸碱失衡的临床意义

肾脏病与透析肾移植杂志 ›› 2013, Vol. 22 ›› Issue (2): 162-165.

早期纠正慢性肾脏病患者酸碱失衡的临床意义

出版日期:2013-04-28 发布日期:2013-04-29

Effect of early correction of acid retention in chronic kidney disease

Online:2013-04-28 Published:2013-04-29

摘要/Abstract

摘要：

摘要：对动物模型的研究显示代谢性酸中毒和/或饮食中产酸食物可以通过肾内机制介导肾脏损伤和肾小球滤过率进行性下降。新近研究支持在慢性肾脏病患者出现代谢性酸中毒之前已出现酸潴留，减少饮食中产酸食物，代之以Na+碱基或产碱食物就具肾保护作用，是现有的肾脏保护措施外又一项肾保护措施。

关键词: 关键词：慢性肾脏病 , 酸潴留 , 碳酸氢盐 , 饮食

Abstract:

ABSTRACT Animal models of chronic kidney disease (CKD) show that metabolic acidosis and/or dietary acid induce intrakidney mechanisms that cause kidney injury and mediate progressive glomerular filtration rate (GFR) decline. Recently studies demonstrated that dietary acid reduction with Na+-based alkali or alkali inducing food ameliorated kidney injury in patients with CKD and reduced GFR, with and without metabolic acidosis, which support that dietary acid reduction with Na+-based alkali or alkali inducing food is an effective kidney-protective adjunct to current strategies.

Key words: Keywords: chronic kidney disease , acid retention , bicarbonate , diet

王金泉，俞雨生. 早期纠正慢性肾脏病患者酸碱失衡的临床意义[J]. 肾脏病与透析肾移植杂志, 2013, 22(2): 162-165.

WANG Jinq-uan, YU Yu-sheng . Effect of early correction of acid retention in chronic kidney disease[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2013, 22(2): 162-165.

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