肥胖相关性肝肾疾病的新机制

肾脏病与透析肾移植杂志 ›› 2011, Vol. 20 ›› Issue (3): 270-274.

肥胖相关性肝肾疾病的新机制

出版日期:2011-06-30 发布日期:2011-08-08

Mechanisms linking obesity, chronic kidney disease and fatty liver disease

Online:2011-06-30 Published:2011-08-08

摘要/Abstract

摘要：

肥胖是肥胖相关性肾病和非酒精性脂肪肝病的重要危险因素。近年来的研究表明，组织内的血清胎球蛋白A（Fetuin-A）和脂联素（Adiponectin），以及5’-AMP激活的蛋白激酶（AMPK）的协同作用是肥胖相关性肝肾疾病的共同机制，在肾脏足细胞和肝实质细胞的损伤中均发挥枢纽作用；引发组织炎症、纤维化，以及终末期硬化。深入研究早期共同通路，有助于发现肥胖相关性疾病治疗的新靶标。

Abstract:

Obesity is a risk factor for chronic kidney disease and nonalcoholic fatty liver disease. Recent studies identify mechanisms common to both disease linked through an interorgan communication orchestrated by Fetuin-A, Adiponectin and 5’-AMP activated protein kinase (AMPK). In liver and kidney, the energy sensor AMPK is pivotal to directing podocytes and hepatocytes to compensatory and potentially deleterious pathways, leading to inflammatory and profibrotic cascades culminating in end-organ damage. Regulation of these early upstream pathways may provide new therapeutic targets for these common sequelae of obesity.

Key words: obesity-related glomerulopathy, honalcoholic fatty liver disease,fetuin-A, adiponectin AMPK

陈慧梅,曾彩虹. 肥胖相关性肝肾疾病的新机制[J]. 肾脏病与透析肾移植杂志, 2011, 20(3): 270-274.

CHEN Hui-mei,ZENG Cai-hong. Mechanisms linking obesity, chronic kidney disease and fatty liver disease[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2011, 20(3): 270-274.

ISSN 1006-298X CN 32-1425/R