关键词: 单克隆免疫球蛋白血症, 肾脏疾病, M蛋白浓度

Abstract: Ｏｂｊｅｃｔｉｖｅ：To discuss the clinical significance of the Mprotein concentration detection in patients with monoclonal immunoglobulinemia.
Ｍｅｔｈｏｄｏｌｏｇｙ：Data from monoclonal immunoglobulin cases screened in our laboratory for 8 months were used to assemble a cohort of 142 cases selected according to immunofixation interpretation.The serum protein electrophoresis and image analysis software were used to detecte the Mprotein concentration.The clinical,laboratory and pathological characteristics of 142 patients with Mprotein were analyzed comprehensively.
Ｒｅｓｕｌｔｓ：A total of 142 patients were included in the study.There were 85 males and 57 females with male predominance,with a median age of 600 years.The Mproteins in that cohort were 620％ IgG,247％ IgA,63％ IgM,49％ free light chain,07％ heavy chain,14％ IgG and IgA;κ accounted for 362％ and λ accounted for 638％ among the light chain types.Monoclonal gammopathy of renal significance (MGRS) accounted for the highest proportion (539％),monoclonal gammopathies of undetermined significance (MGUS,275％),hematopoietic malignancies associated with monoclonal gammopathy (MG) (176％).Patients with hematopoietic malignancies associated with MG had a high medium Mprotein concentration than those with MGRS (425g／L vs.240g／L,P=0019) and MGUS (425 g／L vs.256 g／L,P=0043).The Mprotein concentration was positively correlated with serum calcium,and negatively correlated with total serum cholesterol,24 hour urinary protein (P<005).In patients with hematopoietic malignancies associated with MG,Mprotein concentration was positively correlated with serum creatinine,urea nitrogen and calcium,and negatively correlated with hemoglobin,platelets and total serum cholesterol;in patients with MGRS,it was negatively correlated with total serum cholesterol.
Ｃｏｎｃｌｕｓｉｏｎ：
In this research,patients with monoclonal immunoglobulinemia were mainly elderly men.Patients with hematopoietic malignancies associated with MG had the highest Mprotein concentration.The Mprotein concentration correlated with some laboratory results.

Key words: monoclonal immunoglobulinemia, renal diseases, M-protein concentration