关键词: 维持性血液透析, 心血管钙化, 影响因素

Abstract:

To investigate the influencing factors of the progression of cardiovascular calcification in hemodialysis patients.Ｍｅｔｈｏｄｏｌｏｇｙ：104 cases of patients with maintenance hemodialysis (MHD) were enrolled in this respective study. Coronary artery calcification score (CACS, Agstonscores) was detected by chest spiral CT，abdominal aortic calcification score（AACS，Kauppila score）was determined by abdominal lateral radiographs,and the cardiac valve calcification was examined by cardiac ultrasound.
Results：The baseline cardiovacular calcification rate was 6923%,and it
 the progressed to 8118% after 3 years of followup. The CACS, AACS and valve calcification were significantly worse than the baseline. Logistic regression analysis showed that the E peak/A peak ratio,timeaverage serum phosphorus(TAP),timeaverage calcium phosphorus products (TACa×P), Baseline CACS and calcium carbonate were independent risk factors of CACS progression, and there was statistical significance (P<005). During the study period, 17 patients (1634%) died. Cardiovascular calcification was more significant noticed in patients died of  cerebrocadiovascular reasons.Ｃｏｎｃｌｕｓｉｏｎ：The incidence of vascular calcification in hemodialysis patients was high，and it increases gradually with the prolongation of dialysis time.The level of serum phosphorus、calcium phosphorus product index, baseline CACS were the factors affect the longterm CAC progression.

Key words: maintenance hemodialysis, cardiovascular calcification, influencing factor