ISSN 1006-298X      CN 32-1425/R

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肾脏病与透析肾移植杂志 ›› 2022, Vol. 31 ›› Issue (4): 390-394.DOI: 10.3969/j.issn.1006298X.2022.04.019

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ABO血型不相容肾移植的研究进展

  

  • 出版日期:2022-08-29 发布日期:2022-08-26

Current progress in of ABOincompatible kidney transplantatio

  • Online:2022-08-29 Published:2022-08-26

摘要: 近来随着术前预处理和术后并发症防治的深入研究,ABO血型不相容肾移植(ABOiKT)已成为缓解肾源短缺的重要途径。然而,ABOiKT术后受者仍面临感染、出血和抗体介导的排斥反应(AMR)等问题,影响肾移植受者/移植肾的长期预后。目前有关ABOiKT的研究主要集中在探寻更有效的术前处理及术后并发症的合理防治。本文以现有的术前预处理方案及对ABOiKT术后并发症的防治为切入点,并结合最新研究,探讨未来ABOiKT的研究方向,为进一步提高肾移植受者和移植肾远期存活率提供参考。


关键词: 肾移植ABO血型不相容预处理并发症

Abstract: Recently, with the indepth study of preoperative pretreatment and prevention of postoperative complications, ABO incompatible kidney transplantation (ABOiKT) has become an important way to alleviate kidney shortage. However, patients with ABOiKT still face problems such as infection, bleeding, and antibodymediated rejection, which affect the longterm prognosis of recipients/transplanted kidneys. Current studies on ABOiKT mainly focus on the exploration of more effective preoperative management, reasonable prevention and treatment of postoperative complications. In this paper, based on the existing preoperative management scheme and the prevention and treatment of postoperative complications of ABOiKT as the entry point, combined with the latest research, the future research direction of ABOiKT is discussed, so as to provide reference for further improving the longterm survival rate of kidney transplant recipients and graft.

Key words: kidney transplantation, ABO-incompatible, pretreatmentc, omplications